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For decades, the central dogma of molecular biology emphasized the role of RNA primarily as a messenger carrying genetic information from DNA to proteins. However, the genomic era has revealed that only a small fraction of the human genome codes for proteins, while the vast majority is transcribed into non-coding RNA (ncRNA). These molecules play critical roles in gene regulation, cellular structure, and disease development. To navigate this complex landscape, scientists require comprehensive and standardized resources. The 2021 publication identified by the citation code juq016 , appearing in Nucleic Acids Research , outlines the significant expansion and updates to RNAcentral , the world’s premier database of non-coding RNA sequences. This essay explores the significance of this publication, detailing the database’s expanded capabilities, its role in bioinformatics, and its impact on biological research.
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